Aplastic anaemia is a rare but serious form of bone-marrow failure in which the haematopoietic stem and progenitor cells of the marrow are depleted, leading to pancytopenia, a reduction in red cells, white cells, and platelets, in the peripheral blood. The resulting anaemia, neutropenia, and thrombocytopenia produce…
Aplastic anaemia is a rare but serious form of bone-marrow failure in which the haematopoietic stem and progenitor cells of the marrow are depleted, leading to pancytopenia, a reduction in red cells, white cells, and platelets, in the peripheral blood. The resulting anaemia, neutropenia, and thrombocytopenia produce fatigue, susceptibility to infection, and bleeding, which can be life-threatening. Most cases are acquired and immune-mediated, in which cytotoxic T lymphocytes target haematopoietic stem cells, while others are inherited, as in Fanconi anaemia, or secondary to drugs, toxins, viral infection, or radiation. Diagnosis rests on demonstrating peripheral cytopenias together with a hypocellular bone marrow and excluding other causes of marrow failure such as myelodysplasia. Management is stratified by severity and patient age, encompassing supportive care with transfusion and infection control, immunosuppressive therapy combining antithymocyte globulin and ciclosporin, thrombopoietin-receptor agonists, and allogeneic haematopoietic stem-cell transplantation, which offers the prospect of cure in suitable candidates. The condition sits within the broader study of bone-marrow failure syndromes and haematopoiesis, and the journal publishes peer-reviewed research relevant to haematological disease, including disorders of blood-cell production.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Aplastic Anemia, linking to each citing work.