Multiple myeloma is a malignancy of terminally differentiated plasma cells that accumulate clonally in the bone marrow, producing a monoclonal immunoglobulin or light chain and disrupting normal haematopoiesis. It characteristically gives rise to the constellation of hypercalcaemia, renal impairment, anaemia, and ly…
Multiple myeloma is a malignancy of terminally differentiated plasma cells that accumulate clonally in the bone marrow, producing a monoclonal immunoglobulin or light chain and disrupting normal haematopoiesis. It characteristically gives rise to the constellation of hypercalcaemia, renal impairment, anaemia, and lytic bone disease, together with increased susceptibility to infection, and it is typically preceded by the premalignant states of monoclonal gammopathy of undetermined significance and smouldering myeloma. Diagnosis integrates serum and urine protein studies, marrow examination, imaging, and cytogenetics, while treatment combines immunomodulatory drugs, proteasome inhibitors, corticosteroids, monoclonal antibodies, and autologous stem-cell transplantation. Peer-reviewed work relevant to this topic examines complications such as plasma-cell pleocytosis after bone-marrow transplantation and drug-induced fever during treatment, extraosseous plasmacytoma, stem-cell mobilisation with agents such as plerixafor, infectious complications including invasive aspergillosis in haematology wards, and related plasma-cell and lymphoproliferative disorders such as Waldenström's macroglobulinaemia. These contributions span clinical haematology, transplantation, and supportive care, addressing the biology, complications, and management of plasma-cell malignancy, an area in which the journal publishes peer-reviewed research relevant to leukaemia and haematological disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Multiple Myeloma, linking to each citing work.