Research Topic · Peer-Reviewed

Lupus

Lupus, in its systemic form systemic lupus erythematosus, is a chronic multisystem autoimmune disease in which loss of self-tolerance leads the immune system to produce autoantibodies against nuclear and other cellular components, forming immune complexes that deposit in tissues and drive inflammation. It can affect…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 53× across the literature 🗓 Reviewed July 2026

Overview

Lupus, in its systemic form systemic lupus erythematosus, is a chronic multisystem autoimmune disease in which loss of self-tolerance leads the immune system to produce autoantibodies against nuclear and other cellular components, forming immune complexes that deposit in tissues and drive inflammation. It can affect virtually any organ, including the skin, joints, kidneys, blood, serous membranes, and nervous system, producing a heterogeneous and relapsing-remitting course with manifestations such as fatigue, arthralgia, photosensitive rashes, fever, cytopenias, and nephritis. Its etiology is multifactorial, combining genetic susceptibility, including variants in immune-regulatory genes, with hormonal and environmental triggers, and certain monogenic immune disorders can clinically mimic lupus. Diagnosis is challenging because its protean features overlap with other conditions, and it relies on combinations of clinical criteria and serological markers, while management aims to control inflammation, prevent flares and organ damage, and manage comorbidity. Within the associated literature, autoimmune and immunogenetic themes include adenosine deaminase type 2 deficiency masquerading as lupus, regulatory variant analysis of the STAT4 transcription factor in disease, rare neuroimmunological and autoimmune polyglandular associations, autoantibody-related coagulation abnormalities, and immune thrombocytopenia and its diagnosis. Related work addresses proteomic and genomic techniques in diagnostics and vitamin D status in autoimmune mucosal disease. This journal publishes peer-reviewed research relevant to autoimmune and rheumatic disease, including the immunology and clinical features of lupus.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 53 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Lupus, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Arthritis Research and Therapy.

Journal editorial board
Roberto Paganelli · Italy Riccardi Carlo · Italy Helena Idborg · Sweden

This page summarises published research for orientation; it is not medical or professional advice.