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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JHC</journal-id>
      <journal-title-group>
        <journal-title>Journal of Hypertension and Cardiology</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2329-9487</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.14302/issn.2329-9487.jhc-22-4154</article-id>
      <article-id pub-id-type="publisher-id">JHC-22-4154</article-id>
      <article-categories>
        <subj-group>
          <subject>research-article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Valvular Heart Disease and Pregnancy in the Delivery Room at Yalgado Ouedraogo University Hospital about 12 Cases</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Koudougou</surname>
            <given-names>Jonas Kologo</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540644">1</xref>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Georges</surname>
            <given-names>Rosario Christian Millogo</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540644">1</xref>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mbaye</surname>
            <given-names>Salissou Seck Mbaye</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
          <xref ref-type="aff" rid="idm1842539708">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Relwendé</surname>
            <given-names>Aristide Yaméogo</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540356">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Hermann</surname>
            <given-names>Adoko</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
          <xref ref-type="aff" rid="idm1842539348">5</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Germain</surname>
            <given-names>Mandi</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>W</surname>
            <given-names>Bernard Ouedraogo</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Adolphe</surname>
            <given-names>Zingué</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Anna</surname>
            <given-names>Thiam/Tall</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540644">1</xref>
          <xref ref-type="aff" rid="idm1842540500">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>André</surname>
            <given-names>K. Samadoulougou</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842540644">1</xref>
          <xref ref-type="aff" rid="idm1842541004">3</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1842540644">
        <label>1</label>
        <addr-line>Training and Research Unit in Health Science (UFR/SDS) / University Professor Joseph KI-ZERBO, Ouagadougou </addr-line>
      </aff>
      <aff id="idm1842540500">
        <label>2</label>
        <addr-line>Cardiology Department of the Yalgado Ouédraogo University Hospital, Ouagadougou (Burkina Faso)</addr-line>
      </aff>
      <aff id="idm1842541004">
        <label>3</label>
        <addr-line>University Hospital of Bogodogo (Burkina Faso)</addr-line>
      </aff>
      <aff id="idm1842540356">
        <label>4</label>
        <addr-line>Medical Department of the Regional Hospital of Koudougou (Burkina Faso)</addr-line>
      </aff>
      <aff id="idm1842539348">
        <label>5</label>
        <addr-line>Medical Department of the Regional Hospital of Ouahigouya (Burkina Faso)</addr-line>
      </aff>
      <aff id="idm1842539708">
        <label>*</label>
        <addr-line>Corresponding author</addr-line>
      </aff>
      <author-notes>
        <corresp>
  Mbaye Salissou Seck Mbaye, <addr-line>Cardiology                Department of the Yalgado Ouédraogo University Hospital, Ouagadougou (Burkina Faso)</addr-line><email>cecksalibaye@yahoo.com</email></corresp>
        <fn fn-type="conflict" id="idm1850694164">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2022-04-14">
        <day>14</day>
        <month>04</month>
        <year>2022</year>
      </pub-date>
      <volume>3</volume>
      <issue>2</issue>
      <fpage>32</fpage>
      <lpage>35</lpage>
      <history>
        <date date-type="received">
          <day>04</day>
          <month>04</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>13</day>
          <month>04</month>
          <year>2022</year>
        </date>
        <date date-type="online">
          <day>14</day>
          <month>04</month>
          <year>2022</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>Koudougou Jonas Kologo, et al. </copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/jhc/article/1810">This article is available from http://openaccesspub.org/jhc/article/1810</self-uri>
      <abstract>
        <p>This series summarizes 12 pregnancies complicated by valvular heart disease, focusing on intrapartum management, anesthesia choices, and maternal–fetal outcomes in a resource‑limited setting.</p>
      </abstract>
      <kwd-group>
        <kwd>Heart</kwd>
        <kwd>congenital</kwd>
        <kwd>pregnancy</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="1"/>
        <page-count count="4"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1842531012" sec-type="intro">
      <title>Introduction</title>
      <p>Valvular heart disease is characterized by the presence of acquired or congenital lesion of the heart valves.   They all  reflect narrowings and/or  valve  insufficiency.  These are  common heart        diseases in  developing  countries occurring in young subjects and therefore in women likely to            procreate. </p>
      <p> During pregnancy, several hemodynamics in  pregnants women. These changes without                consequences on a healthy heart can unbalance in these parturients an already precarious cardiac               function  depending on  the underlying cardiovascular involvement <xref ref-type="bibr" rid="ridm1842382900">1</xref>.</p>
      <p>Valvular heart disease during pregnancy is a complex   pathology with a symptomatology capable of affecting the quality of life of the parturient and putting at stake the vital prognosis of the mother and  child.  In  sub-Saharan Africa, only  hospital  data are available <xref ref-type="bibr" rid="ridm1842443956">2</xref>. In Burkina Faso, no studies on valvular heart disease during pregnancy have been conducted. Our study aims to study the association of valvular heart disease and pregnancy in our practice, through epidemiological aspects, management devices and the future of our parturients and newborns.</p>
    </sec>
    <sec id="idm1842530508" sec-type="subjects">
      <title>Patients and Methods </title>
    </sec>
    <sec id="idm1842532092">
      <title>Type and Study Period </title>
      <p>This was a cross-sectional study in the              delivery room of the obstetric gynecology                  department of the Yalgado OUEDRAOGO University           Hospital between January 1, 2015 and March 31, 2016, in  15 months.</p>
      <sec id="idm1842529860">
        <title>Inclusion Criteria</title>
        <p>1. Presence of known acquired valvular heart disease followed or not;</p>
        <p>2. Suspicion of valvular heart disease confirmed by            Doppler echocardiography;</p>
        <p>3. Patient consenting to participate in  the study</p>
      </sec>
      <sec id="idm1842528852">
        <title>Conduct of the Study</title>
        <p>The diagnosis and causes of valvular heart disease have been affirmed on clinical, echocardiographic            arguments.</p>
        <p>The diagnosis of infective endocarditis was          selected on the criteria of DUKES. The diagnosis of acute rheumatic fever was retained on Jones' criteria </p>
        <p>The pregnancy follow-up diary, obstetric             ultrasounds and biological examinations performed were used for the study. The patient record of gynecology was  also used.</p>
        <p>The data collected covered: the mode of discovery of valvular heart disease, its type and etiology, the term of pregnancy, possible complications as well as the             modalities of management and the evolution after delivery for the mother and the newborn.</p>
      </sec>
    </sec>
    <sec id="idm1842527268">
      <title>Statistical Analysis</title>
      <p>The data was processed and analyzed with the EPI-INFO software in its version 7. Respect for anonymity was respected.</p>
    </sec>
    <sec id="idm1842526980" sec-type="results">
      <title>Results</title>
      <p>Twelve patients were collected during the study.  The average age of our patients was 27.5 (standard         deviation) years with extremes of 21 years and 34 years.  Gestational age  at delivery was 35 ± 4.7 weeks of            amenorrhea with extremes of 25 and 39 weeks. The          women had no fixed income (7 out of 12 patients) and 5 patients had never been to school. The geographical origin or provenance of the patient was urban for 8 patients. None of the patients were being followed for valvular heart disease prior to pregnancy. Eleven patients did not  have contraceptive methods in the two years prior to  pregnancy.   Acute rheumatoid arthritis was the etiology of 91.7% of valvular heart disease (11 patients). Infectious endocarditis (one patient) was noted  as the etiology of valvular heart disease.</p>
      <p>The mode of delivery was vaginal in seven cases and caesarean section in three cases. We noted two          spontaneous abortions. Seven newborns were                     hypotrophic with an average birth  weight of 2360g. As complications, two Patients were in global heart failure with a complete arrhythmia type rhythm disorder by    atrial fibrillation were hospitalized in cardiology. No        patient deaths  were recorded in our series. No patients  have had valve  surgery  in our series.</p>
      <p>11 out of 12 patients did not have contraceptive methods in the two years before their pregnancy;                therefore, pregnancies in patients with valvular heart           disease are not planned in agreement with the                   cardiologist. Indeed, none of our patients were followed by a cardiologist.</p>
      <p>Mitral disease accounted for four cases. <xref ref-type="table" rid="idm1841822068">Table 1</xref> shows the distribution of valve damage.</p>
      <table-wrap id="idm1841822068">
        <label>Table 1.</label>
        <caption>
          <title> Type of valvular heart disease according to the valve involved </title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>Monovalvular</bold>
              </th>
              <td>
                <bold>Type of valvular </bold>
              </td>
              <td>
                <bold>Number</bold>
              </td>
              <td>
                <bold>Percentage %)</bold>
              </td>
            </tr>
            <tr>
              <td> </td>
              <td>Mitral shrinkage </td>
              <td>3</td>
              <td>25</td>
            </tr>
            <tr>
              <td> </td>
              <td>Mitral insufficiency</td>
              <td>2</td>
              <td>16,7</td>
            </tr>
            <tr>
              <td> </td>
              <td>Mitral disease  </td>
              <td>4</td>
              <td>33,3</td>
            </tr>
            <tr>
              <td> </td>
              <td>Aortic insufficiency</td>
              <td>1</td>
              <td>8.3</td>
            </tr>
            <tr>
              <td> </td>
              <td>Polyvalvular Mitral </td>
              <td>2</td>
              <td>16.7</td>
            </tr>
            <tr>
              <td> </td>
              <td>Aortic insufficiency</td>
              <td/>
              <td/>
            </tr>
            <tr>
              <td>
                <bold>Total</bold>
              </td>
              <td> </td>
              <td>12</td>
              <td>100</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </sec>
    <sec id="idm1842493796" sec-type="discussion">
      <title>Discussion</title>
      <p>The average age of our patients is 27.5 ± 3.9 years which is the age of childbearing. He agrees with the data of the literature: 26 years <xref ref-type="bibr" rid="ridm1842458932">3</xref>, 27.79 ± 2.99 in Egypt <xref ref-type="bibr" rid="ridm1842449068">4</xref>; this age is slightly higher  in France: 29.2±5.5 years <xref ref-type="bibr" rid="ridm1842240172">5</xref>.</p>
      <p>The first prenatal consultation is done on the         periphery in the absence of a cardiologist.  Also</p>
      <p> The  average term of  pregnancy being  35.5 ± 4.7 weeks of amenorrhea proves that  most deliveries are premature.  In addition, this period corresponds to the moment when physiological changes are very important, especially with the increase in  volume  responsible for a defusing of the heart pump. This would be at the origin of the decompensation of valvular heart disease and at the same time the mode of discovery. The average birth weight is 2360 g with seven hypotrophic newborns. This peculiarity is observed by Belhani <xref ref-type="bibr" rid="ridm1842244996">6</xref> in Tunisia, and         Al-Lawati in Oman <xref ref-type="bibr" rid="ridm1842223660">7</xref>. It is also explained in our context by a  precarious nutritional status and the premature         delivery  of  newborns in most  cases.</p>
      <p>None of the patients were known to have  valvular heart disease.  This is explained by the lack of a program for the management of valvular heart disease and the fight against rheumatic fever leading to a late diagnosis of these pathologies at the complication stage. Early diagnosis and appropriate follow-up would prevent complications for both mothers and new mothers through proper                  pregnancy planning.</p>
      <p>  The perioperative period is grafted with                    cardiovascular complications in patients with valvular heart disease in the decompensation phase. The risk of major cardiovascular events is about greater than 5% in tight MR with a mitral area of less than 1.5 cm<sup>2</sup>, while it is less than 1% in mr with little symptoms <xref ref-type="bibr" rid="ridm1842228556">8</xref>. Two of our MR patients were operated on for global heart failure with a complete arrhythmia rhythm disorder by atrial                 fibrillation and were hospitalized in cardiology. For                patients with NYHA stage III dyspnea, however, this risk is increased by up to 7% <xref ref-type="bibr" rid="ridm1842218908">9</xref>; the presence of symptoms such as heart failure in our patients is a formal indication of caesarean section <xref ref-type="bibr" rid="ridm1842215884">10</xref>. Several safety measures must be   undertaken during  perioperative management such as increasing the pre-load of the left ventricle, fighting                 tachycardia, rhythm disorders, and hypovolemia; and           rapid correction of hypoxia, hypercapnia, so as not to              aggravate latent PAH <xref ref-type="bibr" rid="ridm1842202852">12</xref>. These measures were taken in our two parturients and the surgical follow-up was               simple. </p>
      <p>No patient in our series has received valve repair surgery because it is not yet performed in Burkina Faso. These patients benefited from a treatment based on               diuretics thus complicating the nutritional management of newborns in our context.</p>
    </sec>
    <sec id="idm1842471412" sec-type="conclusions">
      <title>Conclusion</title>
      <p>In Burkina Faso, the association of pregnancy and valvular heart disease is becoming more and more                    frequent due to the persistence of acute rheumatic fever. It is at the origin of an alteration in the quality of life of               parturients and engages the vital prognosis of the mother and the child. Pregnancy  in patients with valvular heart disease should be planned with the cardiologist. The            management of   patients involves  the prevention of    rheumatic fever but also a joint follow-up of patients by  gynecologists and cardiologists.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ridm1842382900">
        <label>1.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>B</surname>
            <given-names>A Diallo</given-names>
          </name>
          <name>
            <surname>Sanogo</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Diakité</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Mb</surname>
            <given-names>Diarra</given-names>
          </name>
          <article-title>Pregnancy and heart failure association: sociodemographic, clinical and prognostic features</article-title>
          <date>
            <year>2004</year>
          </date>
          <source>TXIX N°2 PP 15 –</source>
          <chapter-title>Study of 20 cases Mali medical</chapter-title>
          <volume>17</volume>
        </mixed-citation>
      </ref>
      <ref id="ridm1842443956">
        <label>2.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Ben</surname>
            <given-names>Aissia N</given-names>
          </name>
          <name>
            <surname>Essid</surname>
            <given-names>I</given-names>
          </name>
          <name>
            <surname>Gara</surname>
            <given-names>Med F</given-names>
          </name>
          <article-title>The pregnancy and the delivery particularities at the women bearing of rhumatismal valvulopathy ; Société tunisienne des sciences médicales ;</article-title>
          <date>
            <year>2003</year>
          </date>
          <volume>81</volume>
          <issue>5</issue>
          <fpage>334</fpage>
          <lpage>338</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842458932">
        <label>3.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Iturbe-Alessio</surname>
            <given-names>I</given-names>
          </name>
          <name>
            <surname>M</surname>
            <given-names>Del Carmen Fonseca</given-names>
          </name>
          <name>
            <surname>Mutchinik</surname>
            <given-names>O</given-names>
          </name>
          <article-title>Risk of anticoagulant therapy in pregnant woman with artificial heart valves</article-title>
          <date>
            <year>1986</year>
          </date>
          <source>New Eng J Med</source>
          <volume>315</volume>
          <fpage>1390</fpage>
          <lpage>1393</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842449068">
        <label>4.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Mansy</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Zaky</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Abdelmeguid</surname>
            <given-names>I</given-names>
          </name>
          <article-title>Anticoagulation in pregnant women with mechanical heart valve prostheses</article-title>
          <date>
            <year>2003</year>
          </date>
          <source>J. of Egypt. Society of Cardiothorac. Surg</source>
          <volume>4</volume>
          <fpage>1</fpage>
          <lpage>9</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842240172">
        <label>5.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Hanania</surname>
            <given-names>G</given-names>
          </name>
          <name>
            <surname>Thomas</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>Michel</surname>
            <given-names>P L</given-names>
          </name>
          <article-title>Pregnancies in valvular prosthesis carriersFrench retrospective cooperative study (155 cases)</article-title>
          <date>
            <year>1994</year>
          </date>
          <source>Arch Mal Coeur</source>
          <volume>87</volume>
          <fpage>429</fpage>
          <lpage>437</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842244996">
        <label>6.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Belhani</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Kachboura</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Abdelkader</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Bennaceur</surname>
            <given-names>M</given-names>
          </name>
          <article-title>Valve prostheses and pregnancies</article-title>
          <date>
            <year>1990</year>
          </date>
          <volume>68</volume>
          <fpage>597</fpage>
          <lpage>602</lpage>
          <publisher-loc>Tunis. Med</publisher-loc>
        </mixed-citation>
      </ref>
      <ref id="ridm1842223660">
        <label>7.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Al-lawati</surname>
            <given-names>A M</given-names>
          </name>
          <name>
            <surname>Venkitraman</surname>
            <given-names>M</given-names>
          </name>
          <article-title>Pregnancy and mechanical heart valves replacement: dilemma of anticoagulation</article-title>
          <date>
            <year>2002</year>
          </date>
          <source>Eur J Cardiothorac surg</source>
          <volume>22</volume>
          <fpage>223</fpage>
          <lpage>227</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842228556">
        <label>8.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Lupton</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Oteng-Ntim</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Ayida</surname>
            <given-names>G</given-names>
          </name>
          <name>
            <surname>Steer</surname>
            <given-names>P J</given-names>
          </name>
          <article-title>Cardiac disease in pregnancy</article-title>
          <date>
            <year>2002</year>
          </date>
          <source>Curr Opin Obstet Gynecol</source>
          <volume>14</volume>
          <fpage>137</fpage>
          <lpage>43</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842218908">
        <label>9.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Sawhney</surname>
            <given-names>H</given-names>
          </name>
          <name>
            <surname>Aggarwal</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Suri</surname>
            <given-names>V</given-names>
          </name>
          <name>
            <surname>Vasishta</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Sharma</surname>
            <given-names>Y</given-names>
          </name>
          <name>
            <surname>Grover</surname>
            <given-names>A</given-names>
          </name>
          <article-title>Maternal and perinatal outcome in rheumatic heart disease. Int J Gynecol Obstet</article-title>
          <date>
            <year>2003</year>
          </date>
          <volume>80</volume>
          <fpage>9</fpage>
          <lpage>14</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842215884">
        <label>10.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <article-title>The task force on the management of cardiovascular diseases during pregnancy of the European Society of Cardiology. Expert consensus document on management of cardiovascular diseases during pregnancy. Eur Heart J</article-title>
          <date>
            <year>2003</year>
          </date>
          <volume>24</volume>
          <issue>8</issue>
          <fpage>761</fpage>
          <lpage>81</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842211780">
        <label>11.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Reimold</surname>
            <given-names>S C</given-names>
          </name>
          <name>
            <surname>Rutherford</surname>
            <given-names>J D</given-names>
          </name>
          <article-title>Valvular heart disease in pregnancy</article-title>
          <date>
            <year>2003</year>
          </date>
          <source>New Engl J Med</source>
          <volume>349</volume>
          <fpage>52</fpage>
          <lpage>9</lpage>
        </mixed-citation>
      </ref>
      <ref id="ridm1842202852">
        <label>12.</label>
        <mixed-citation xlink:type="simple" publication-type="book"><name><surname>Holland</surname><given-names>J</given-names></name><article-title>Anesthesia of a patient with cardiovascular pathology for non-cardiac surgery</article-title><date><year>2000</year></date><chapter-title>The book of internal anesthesiology</chapter-title><fpage>251</fpage><lpage>67</lpage>
In: Bonnet F, Soulier A, Spielvogel C eds
<publisher-loc>Paris: Flammarion</publisher-loc></mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
