Pathogenesis is the sequence of biological events through which a disease originates and develops, from initiating cause through the cellular, molecular, and physiological changes that produce clinical manifestations. It encompasses the interaction of host, agent, and environment, the disruption of normal regulatory…
Pathogenesis is the sequence of biological events through which a disease originates and develops, from initiating cause through the cellular, molecular, and physiological changes that produce clinical manifestations. It encompasses the interaction of host, agent, and environment, the disruption of normal regulatory pathways, and the progression from molecular lesion to tissue dysfunction and organ damage. Understanding pathogenesis underpins risk-factor identification, diagnosis, and the rational design of targeted therapy. The peer-reviewed research collected here reflects these themes through studies of haematological disturbances in dengue haemorrhagic fever, the histologic, genetic, and molecular characteristics of meningioma development and progression, and bioinformatic analysis of variants implicated in the pathogenesis of atherosclerosis. Metabolic and molecular contributions examine familial combined hyperlipidemia and its association with metabolic syndrome, the role of amino acids and their derivatives in liver disease, and biological networks underlying disease mechanisms. Further work addresses immune dysfunction in frailty, trace-element content in thyroid malignancy, and mast-cell dynamics in lymphoproliferative disease, illustrating diverse mechanistic pathways. Methodologically, the literature draws on clinical and histopathological analysis, molecular and metabolic profiling, bioinformatics, and review synthesis, illustrating how pathogenesis connects molecular and cellular dysfunction to clinical disease across infectious, neoplastic, cardiovascular, and metabolic conditions, and how mechanistic insight informs diagnosis and treatment.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 138 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Pathogenesis, linking to each citing work.