Tumor suppressor genes are genes whose normal function is to restrain cell growth and division, repair DNA, or trigger programmed cell death, thereby protecting against the uncontrolled proliferation that leads to cancer. When these genes are inactivated by mutation, deletion, or epigenetic silencing, their protecti…
Tumor suppressor genes are genes whose normal function is to restrain cell growth and division, repair DNA, or trigger programmed cell death, thereby protecting against the uncontrolled proliferation that leads to cancer. When these genes are inactivated by mutation, deletion, or epigenetic silencing, their protective braking action is lost and tumor formation becomes more likely. In cancer genetics and molecular biology, tumor suppressor genes are studied alongside oncogenes as key drivers of malignant transformation. Research examines how their loss contributes to the development and progression of tumors, including the histologic, genetic, and molecular characteristics of meningioma pathogenesis and the role of genes in tumor formation more broadly. Regulatory layers beyond DNA sequence are also central, with studies on epigenetics and nutrition and on microRNAs, such as microRNA-1285's potential regulation of the OCT4 gene and the correlation of miR-21 expression with poor survival in esophageal cancer. The journal publishes work connecting these mechanisms to diagnosis and clinical management, including microRNA quantification by digital PCR for colorectal cancer screening, serrated lesions as a pathway in colorectal carcinogenesis, molecular diagnosis of thyroid cancer, and chromosomal abnormalities in leukemia. Together these studies illustrate how the disruption of tumor suppressor function, and the gene-regulatory networks surrounding it, underlies cancer biology and informs molecular diagnostics and potential therapeutic targets.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Tumor Suppressor Genes, linking to each citing work.