Headache is one of the most common neurological symptoms, defined as pain perceived in any region of the head, arising from activation of pain-sensitive structures including cranial blood vessels, meninges, and the trigeminal sensory system rather than the brain parenchyma itself. Headache disorders are classified a…
Headache is one of the most common neurological symptoms, defined as pain perceived in any region of the head, arising from activation of pain-sensitive structures including cranial blood vessels, meninges, and the trigeminal sensory system rather than the brain parenchyma itself. Headache disorders are classified as primary, where the headache is the disorder itself, as in migraine, tension-type headache, and cluster headache, or secondary, where pain results from an underlying cause such as vascular, infectious, structural, or systemic disease. Pathophysiology involves trigeminovascular activation, neurogenic inflammation, altered cerebral hemodynamics, and central sensitization, with cerebrovascular reactivity implicated in several subtypes. Research relevant to this area examines brain hemodynamics and cerebrovascular reactivity in tension-type headache, headache as a presenting feature of chiasmal, vascular, and posterior encephalopathy syndromes, and the diagnostic evaluation of neurological disorders in which headache figures prominently. Allied work addresses the methodology of therapeutic clinical research in neurological disease, self-medication practices, and secondary causes including infarction and structural lesions. Accurate classification and identification of secondary causes are central to safe management. The journal publishes peer-reviewed research relevant to headache and its neurological context, including cerebrovascular reactivity, secondary causes, and the clinical evaluation of headache-associated disorders.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 22 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Headache, linking to each citing work.