Overview
Monoclonal antibodies are identical antibody molecules produced from a single B-cell clone, engineered to recognise and bind one specific antigenic target with high precision. Their defined specificity makes them powerful tools in diagnostics, research, and therapeutics, where they neutralise pathogens, block signalling pathways, or flag cells for immune attack. A central principle is the isolation and generation of antibodies against defined targets, illustrated by single-chain variable fragment antibodies raised against particular receptor complexes, which extends antibody technology to molecules such as neurotransmitter-receptor heteromers. In infectious disease, antibody-based strategies include the use of neutralising antibodies and convalescent immune plasma, while immunoassays and immunogenomic approaches employ antibodies for the monitoring of cancer and infection. In oncology, therapeutic antibodies that block immune-checkpoint pathways, such as the programmed cell death protein-1 axis, are used to treat malignancies including melanoma, and proteomic methods track cellular responses to antibody-directed treatments. Antibodies also serve experimental roles in detecting proteins, characterising cellular senescence, and assessing immune responses to vaccination. Research in this area develops and isolates antibodies of defined specificity, applies them to diagnosis and immunomonitoring, and evaluates their therapeutic use across cancer, infectious disease, and other conditions where targeted molecular recognition is required.
Research published in this journal
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The Novel Coronavirus 2019 (COVID-19): A Narrative Review
The Current Immunoassays and Emerging Immunogenomic Approaches for Immunomonitoring Cancer and Infectious Diseases
Presentation of Neutralizing Antibodies in Single- or Pooled-Convalescent Immune Plasma from Donors to Prevent the Current SARS-CoV-2 Pandemic
Survival among Breast Cancer Patients in a Tertiary Cancer Center in Brunei Darussalam
Blockade of Programmed Cell Death Protein-1 Pathway for the Treatment of Melanoma
Human Myxomatous Mitral Valves Exhibit Focal Expression of Cartilage-Related Proteins
Cytoplasmic Retention of CDC6 Induces Premature Senescence in Immortalized Cells and Suppresses Tumor Formation in Mice
The NH2-Terminal Ig Domains of Insect Projectin could serve as Elastic Elements
Determination of the Proteomic Response to Lapatinib Treatment using a Comprehensive and Reproducible Ion-Current-Based Proteomics Strategy
Assessment of the Immune Response Induced in Neonatal Calves by Vaccination with Mycobacterium Bovis BCG Phipps Under Field Conditions
Optimization and ZSPORE Analysis of Affinity Purification Coupled with Tandem Mass Spectrometry in Mammalian Cells
How this research is being cited
The 12 articles above have been cited 72 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · BMC Bioinformatics
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2025 · BMC Veterinary Research
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2025 · BMC Veterinary Research
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2024 · Experimental Dermatology
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2024 · Experimental Dermatology
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2024 · WIREs Mechanisms of Disease
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2023 · Biosensors and Bioelectronics
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2023 · International Immunopharmacology
A sample of recent works citing this journal's research on Monoclonal Antibodies, linking to each citing work.