Research Topic · Peer-Reviewed

Adenosine

Adenosine is a purine nucleoside composed of the nitrogenous base adenine joined to a ribose sugar, and it occupies a central place in cellular biochemistry. As the structural core of the adenine nucleotides, it contributes to energy currency molecules and to cofactors essential for metabolism, while as a signaling …

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 29× across the literature 🔖 ISSN 2377-2549 🗓 Reviewed July 2026

Overview

Adenosine is a purine nucleoside composed of the nitrogenous base adenine joined to a ribose sugar, and it occupies a central place in cellular biochemistry. As the structural core of the adenine nucleotides, it contributes to energy currency molecules and to cofactors essential for metabolism, while as a signaling molecule it acts through specific adenosine receptors to modulate vascular tone, cardiac conduction, neurotransmission, and inflammatory responses. Its metabolism is tightly controlled: adenosine deaminase converts adenosine to inosine, and genetic deficiency of adenosine deaminase type 2 produces a systemic inflammatory and vascular disorder, illustrating the consequences of disrupted purine handling. Within chemistry, adenosine and modified nucleoside analogues are important synthetic targets, exemplified by fluorinated nucleoside chemistry related to clofarabine, where structural modification yields compounds with antiproliferative and therapeutic potential. Adenosine is also linked physiologically to methylxanthines such as caffeine, which act as receptor antagonists, and to enzymes of purine catabolism including xanthine oxidase. Research spanning synthetic nucleoside chemistry, enzymology, and pharmacology continues to explore adenosine's roles in cardiovascular regulation, neurological function, immune signaling, and the development of nucleoside-based drugs for cancer and other diseases.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

Caffeine Components Empower the Brain Potentiality

Nasim Habibzadeh SeyedehCorresponding author
PhD student in Sport Science, School of Health and Life Sine, Department of Sport Science, Teesside University, United Kingdom
Exact topic Spine and Neuroscience doi:10.14302/issn.2694-1201.jsn-20-3523

How this research is being cited

The 11 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Adenosine, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Annarita Del Gatto · Italy Bharat Gurale · United States Palani ELUMALAI · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.