Insulin resistance is a metabolic state in which target tissues, principally skeletal muscle, liver and adipose tissue, respond subnormally to insulin, so that higher circulating insulin concentrations are required to maintain glucose homeostasis. It reflects impaired insulin-receptor signalling and downstream gluco…
Insulin resistance is a metabolic state in which target tissues, principally skeletal muscle, liver and adipose tissue, respond subnormally to insulin, so that higher circulating insulin concentrations are required to maintain glucose homeostasis. It reflects impaired insulin-receptor signalling and downstream glucose disposal, and is closely linked to visceral adiposity, ectopic lipid accumulation, chronic low-grade inflammation and altered adipose-tissue physiology. As a central feature of the metabolic syndrome, insulin resistance precedes and predicts type 2 diabetes and is associated with dyslipidaemia, hypertension and increased cardiovascular risk. It is assessed through fasting glucose and insulin, surrogate indices of sensitivity, and dynamic testing, and is modulated by diet, physical activity, body composition, hormonal status and pharmacological or nutraceutical interventions. Research grouped under this term reflects these themes: cinnamon supplementation and insulin resistance in polycystic ovary syndrome, dietary regimens for obesity reversal, antioxidant micronutrients in metabolic syndrome, metabolomic bioinformatics in type 2 diabetes, identification of insulin-sensitive versus insulin-resistant obese postmenopausal women, adipose-tissue physiology in obesity, exercise effects on irisin, and gene-polymorphism associations with obesity and diabetes. The peer-reviewed literature in this area examines the determinants, assessment and management of impaired insulin action, integrating nutrition, body composition and metabolic risk in obesity and type 2 diabetes.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Insulin Resistance, linking to each citing work.