Research Topic · Peer-Reviewed

Glutathione

Glutathione is a ubiquitous tripeptide thiol composed of glutamate, cysteine, and glycine, and it is the principal low-molecular-weight antioxidant in plant and animal cells. Existing in reduced (GSH) and oxidized (GSSG) forms, it buffers cellular redox state, scavenges reactive oxygen species and free radicals dire…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 102× across the literature 🔖 ISSN 2637-6075 🗓 Reviewed July 2026

Overview

Glutathione is a ubiquitous tripeptide thiol composed of glutamate, cysteine, and glycine, and it is the principal low-molecular-weight antioxidant in plant and animal cells. Existing in reduced (GSH) and oxidized (GSSG) forms, it buffers cellular redox state, scavenges reactive oxygen species and free radicals directly and through glutathione peroxidase, and detoxifies xenobiotics and electrophiles via glutathione S-transferase conjugation. Glutathione also regenerates other antioxidants such as ascorbate, supports protein thiol homeostasis, and participates in the ascorbate-glutathione cycle that protects against oxidative stress in plants. Disturbed glutathione status and oxidative imbalance are implicated in tissue injury, aging, neurodegeneration, and stress responses across organisms, including the mitigation of heavy-metal and chemical toxicity in plants and the protection of mammalian tissues from oxidative damage. Research relevant to this area examines protection against carbon tetrachloride hepatotoxicity, oxidative telomere attrition and nutritional antioxidants in biological aging, flavonoid antioxidant protection of the heart against oxidative injury, triacontanol-mediated alleviation of nickel toxicity and enhancement of the antioxidant system in maize, oxidative stress and apoptosis in tissue, and quercetin-mediated protection against rotenone-induced toxicity. This peer-reviewed literature reflects the redox biology, detoxification, and stress-protective roles of glutathione across plant and animal systems, situating this antioxidant within the broader study of oxidative stress and organismal physiology.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 102 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Glutathione, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Plant and Animal Ecology (ISSN 2637-6075).

Journal editorial board
Dimitris Zianis · Greece Jasmin Mantilla Contreras · Germany Narcisa Vrinceanu · Romania

This page summarises published research for orientation; it is not medical or professional advice.