Functional Genomics

Overview

Functional genomics is the field of molecular biology that seeks to understand the functions and interactions of genes and other genomic elements, moving beyond cataloguing sequences to determining what they do and how they are regulated. Whereas structural genomics describes the content and organization of genomes, functional genomics asks how genes are transcribed, translated, and controlled, and how their products operate within cells and whole organisms. It exploits genome-wide and high-throughput approaches, including transcriptomics to measure gene expression, proteomics to characterize the proteins encoded, and gene expression and perturbation analyses to link genotype to phenotype. By integrating these data, functional genomics elucidates regulatory networks, signalling pathways, and the cellular consequences of genetic variation, often with the support of bioinformatics to manage and interpret large and complex datasets. The approach illuminates normal developmental and physiological processes and the molecular basis of disease, for example by analyzing gene expression changes that accompany altered cellular behavior, and it informs the identification of biomarkers and therapeutic targets. Functional genomics also underpins applications in biotechnology, where understanding gene function guides the engineering of organisms and the development of products. As sequencing, profiling, and computational tools advance, functional genomics increasingly connects molecular information across DNA, RNA, and protein levels, providing a systems-level view of how genomes generate the functions of living cells and organisms.

Research published in this journal

8 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 8 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia
  2026 · Biochemical Pharmacology
• Association of peripheral blood NLRP3, sTREM2, and p-tau217 levels with cognitive outcomes in patients with chronic alcohol-related brain damage
  2026 · Alcohol and Alcoholism
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  Hami Hemati et al. · 2025 · Brain, behavior, and immunity
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  2025 · Brain Behavior and Immunity
• Bioinformatics: Challenges in Integrating Biological Information
  2022 · JURNAL BIOLOGI TROPIS
• Proteome Wide Screening of Potential Vaccine Targets Against Brucella Melitensis
  2022 · SSRN Electronic Journal
• Introduction to Bioinformatics
  2021 · Springer eBooks
• CRISPR/Cas9 Ribonucleoprotein-Based Genome Editing Methodology in the Marine Protozoan Parasite Perkinsus marinus
  2021 · Frontiers in Bioengineering and Biotechnology

A sample of recent works citing this journal's research on Functional Genomics, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

Related topics