Research Topic · Peer-Reviewed

Gene Regulation

Gene regulation is the molecular control of when, where, and how much a gene is expressed, coordinating the genome's output to meet the demands of development, homeostasis, and adaptation. It operates across multiple layers: transcriptional control by transcription factors binding regulatory elements—including the m…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 57× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed October 2026

Overview

Gene regulation is the molecular control of when, where, and how much a gene is expressed, coordinating the genome's output to meet the demands of development, homeostasis, and adaptation. It operates across multiple layers: transcriptional control by transcription factors binding regulatory elements—including the modulation of binding by regulatory single-nucleotide polymorphisms (rSNPs), as analyzed computationally for EPAS1 and STAT4; epigenetic mechanisms such as DNA methylation and histone modification; and post-transcriptional and post-translational regulation. Non-coding RNAs, including circular RNAs implicated in Alzheimer's disease, add further regulatory specificity, while protein regulators such as optineurin (FIP-2) govern downstream chemokine and kinase expression. These mechanisms shape disease processes and physiological states, illustrated by glucocorticoid receptor–mediated regulation of RNF43 in colorectal cancer, epigenetic control of brain-derived neurotrophic factor expression in chronic pain, and the influence of nutrition and dietary exposures on epigenetic programming. Regulatory variation is also examined through disease-associated polymorphisms such as TREM2 and MS4A6A and through bioinformatic analysis of coronary-disease loci, while evolutionary conservation of developmental regulators—exemplified by Hox genes in brain development—connects regulation to body-plan and lineage divergence. Molecular biomarkers further link regulatory states to function, as in probiotic anti-inflammatory activity. The journal publishes peer-reviewed research on transcription-factor and regulatory-SNP analysis, epigenetic regulation, and non-coding-RNA mechanisms.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Kenneth LundstromCorresponding author
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 57 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Gene Regulation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Juan Sainz · Spain Bobbie-Jo M. Webb-Robertson · United States Feng Ding · China

This page summarises published research for orientation; it is not medical or professional advice.