Overview
Gene expression is the process by which the information encoded in a gene is converted into a functional product, typically through transcription of DNA into RNA and translation of messenger RNA into protein, with regulation at each stage determining which genes are active, when, and to what degree. As a core subject of genetics and genomics, the study of gene expression encompasses the control mechanisms, including transcriptional regulation, RNA processing, and post-transcriptional and translational influences, that shape cellular identity, development, and responses to stimuli. Genome-wide and targeted approaches allow expression to be measured across many genes simultaneously, linking transcriptional patterns to phenotype and disease. In cancer biology, gene-expression analysis is used to dissect mechanisms such as acquired resistance to apoptosis in colorectal cancer cells, revealing how altered expression underlies tumour behaviour. The integration of genomic and proteomic techniques in medical research connects gene expression to downstream protein abundance and function, supporting applications in diagnostics, biomarker discovery, and personalized medicine. Genetic variation, including polymorphisms affecting specific loci, can modulate expression and contribute to disease susceptibility, as explored in studies relating molecular markers to clinical phenotypes. By characterizing how and when genes are expressed and how this is disrupted in disease, the field provides a foundation for understanding biological function, identifying molecular biomarkers, and informing targeted diagnostic and therapeutic strategies.
Research published in this journal
7 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Mechanisms Associated with Acquisition of Resistance to Butyrate-Induced Apoptosis in Colorectal Cancer Cells Using Gene Expression Analysis
Editorial for Journal of Proteomics and Genomics Research: Second Issue
Human Proteome Project and Current Bioinformatics Status in Disease Diagnosis and Treatment
Shotgun Label-Free Proteomic Analyses of the Oyster Parasite Perkinsus Marinus
Molecular Biomarkers: A Brief Review
How this research is being cited
The 7 articles above have been cited 19 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · Biochemical Pharmacology
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2026 · Alcohol and Alcoholism
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Hami Hemati et al. · 2025 · Brain, behavior, and immunity
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2025 · Brain Behavior and Immunity
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2021 · Frontiers in Bioengineering and Biotechnology
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2021 · Tropical Medicine and Infectious Disease
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2021 · Tropical Medicine and Infectious Disease
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2021 · Frontiers in Bioengineering and Biotechnology
A sample of recent works citing this journal's research on Genetics and Genomics Gene Expression, linking to each citing work.