Research Topic · Peer-Reviewed

Proteomics of Metabolic Liver Disorders

Proteomics of metabolic liver disorders is the large-scale study of the proteins expressed in the liver and circulation under metabolic disease, aiming to map how protein abundance, modification, and interaction change as hepatic metabolism is disturbed. The liver is central to lipid, carbohydrate, and protein metab…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 58× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed July 2026

Overview

Proteomics of metabolic liver disorders is the large-scale study of the proteins expressed in the liver and circulation under metabolic disease, aiming to map how protein abundance, modification, and interaction change as hepatic metabolism is disturbed. The liver is central to lipid, carbohydrate, and protein metabolism, and disorders such as fatty liver disease, alcohol-related injury, and related metabolic conditions alter the hepatic proteome in ways that illuminate underlying pathways and may yield diagnostic and therapeutic targets. The field relies on mass-spectrometry-based proteomics, including quantitative strategies such as stable-isotope labeling and ion-current-based and label-free approaches, together with bioinformatic interpretation, to discover and measure proteins, characterize the response to drugs and stressors, and compare healthy and diseased states. Studies of liver enzymes and circulating markers, for example plasma proteins linked to alcohol use and genetic polymorphism, illustrate how proteomic and biomarker analysis connects molecular changes to clinical phenotype. By quantifying differential protein expression and integrating it with genomic information, this work seeks to define the molecular signatures of metabolic liver injury, clarify mechanisms of disease progression, and identify candidate biomarkers for diagnosis and monitoring. Proteomics of metabolic liver disorders thus joins analytical chemistry, hepatology, and systems biology to interpret how metabolic stress reshapes the protein landscape of the liver and the blood.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Quantitative Proteomics Using 15N SILAC Mouse

I. Chen EmilyCorresponding author
Stony Brook University, Proteomics Center, School Of Medicine, NY
Proteomics and Genomics Research Cited by 4 doi:10.14302/issn.2326-0793.jpgr-13-252
2017

Shotgun Label-Free Proteomic Analyses of the Oyster Parasite Perkinsus Marinus

C. P. Figueiredo HenriqueCorresponding author
AQUACEN, National Reference Laboratory for Aquatic Animal Diseases, Ministry of Agriculture, Livestock and Food Supply, Federal University of Minas Gerais, Belo Horizonte, Brazil
Proteomics and Genomics Research Cited by 11 doi:10.14302/issn.2326-0793.JPGR-17-1571

How this research is being cited

The 9 articles above have been cited 58 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Proteomics of Metabolic Liver Disorders, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Sutopa Dwivedi · United States Liuyang Wang · United States Juan Sainz · Spain

This page summarises published research for orientation; it is not medical or professional advice.