Research Topic · Peer-Reviewed

Myasthenia Gravis

Myasthenia gravis is a chronic autoimmune disorder of neuromuscular transmission characterised by fluctuating, fatigable weakness of voluntary muscles. It results from antibodies, most commonly directed against the nicotinic acetylcholine receptor and in some patients against muscle-specific kinase or related postsy…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 41× across the literature 🔖 ISSN 2832-4048 🗓 Reviewed July 2026

Overview

Myasthenia gravis is a chronic autoimmune disorder of neuromuscular transmission characterised by fluctuating, fatigable weakness of voluntary muscles. It results from antibodies, most commonly directed against the nicotinic acetylcholine receptor and in some patients against muscle-specific kinase or related postsynaptic proteins, that impair signalling at the neuromuscular junction by blocking, cross-linking, and complement-mediated destruction of receptors. The reduced density of functional receptors diminishes the safety margin of transmission, producing weakness that worsens with activity and improves with rest, typically affecting ocular, bulbar, limb, and respiratory muscles. The thymus is frequently abnormal, with hyperplasia or thymoma, linking the disease to broader disturbances of immune tolerance, and myasthenia may coexist with other autoimmune and neuroimmunological conditions. Diagnosis combines clinical assessment with antibody testing, electrophysiology demonstrating decremental responses, and pharmacological evaluation, while treatment encompasses acetylcholinesterase inhibitors, immunosuppression, immunomodulation, and thymectomy. The peer-reviewed research associated with this topic addresses myasthenia in the context of antisynthetase antibody syndrome, rare associations between neuroimmunological diseases and autoimmune polyglandular syndromes, and thymic pathology, alongside experimental work on cardiac and cellular biomarkers, reflecting the disorder's basis in autoantibody-mediated failure of neuromuscular transmission and its relationship to thymic and systemic autoimmune dysfunction.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2021

How this research is being cited

The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Myasthenia Gravis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Skeletal Muscle (ISSN 2832-4048).

Journal editorial board
Gerhard Meissner · United States Min Du · United States Jeong-Rae Kim · South Korea

This page summarises published research for orientation; it is not medical or professional advice.