Research Topic · Peer-Reviewed

Sarcopenia

Sarcopenia is the progressive, generalised loss of Skeletal Muscle mass, strength, and function associated with ageing and with catabolic disease states. It reflects an imbalance between muscle protein synthesis and breakdown, driven by factors including anabolic resistance, hormonal change, mitochondrial dysfunctio…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 30× across the literature 🔖 ISSN 2832-4048 🗓 Reviewed July 2026

Overview

Sarcopenia is the progressive, generalised loss of Skeletal Muscle mass, strength, and function associated with ageing and with catabolic disease states. It reflects an imbalance between muscle protein synthesis and breakdown, driven by factors including anabolic resistance, hormonal change, mitochondrial dysfunction, chronic low-grade inflammation, reduced physical activity, inadequate protein and energy intake, and impaired regenerative capacity of muscle satellite cells. Clinically it is assessed through measures of muscle mass, grip strength, and physical performance, and it predisposes to frailty, falls, disability, impaired metabolic regulation, and adverse health outcomes. Sarcopenia frequently coexists with osteoarthritis, obesity, and malnutrition, and overlaps with cachexia in cancer and other wasting conditions, making nutritional assessment and intervention central to its management alongside resistance exercise. Research in this area examines the cellular mechanisms of satellite-cell decline and impaired regeneration, the contribution of vitamin D and protein-energy nutrition, body-composition methods, and transcriptomic analysis of muscle. The peer-reviewed research collected under this topic addresses vitamin D and sarcopenia severity in older adults, grip strength as a nutritional assessment tool, frailty and immune function, satellite-cell self-renewal and regenerative proliferation, body-composition modelling, and transcriptomic approaches to Skeletal Muscle, reflecting the field's integration of muscle biology, nutrition, and geriatric assessment in understanding and counteracting age- and disease-related muscle loss.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2017

Frailty and the Immune System

Wilson DaisyCorresponding author
Institute of Ageing and Inflammation, University of Birmingham, Edgbaston, Birmingham, UK, B15 2GW
Exact topic Aging Research And Healthcare Cited by 19 doi:10.14302/issn.2474-7785.jarh-17-1578

How this research is being cited

The 12 articles above have been cited 30 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Sarcopenia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Skeletal Muscle (ISSN 2832-4048).

Journal editorial board
Gerhard Meissner · United States Min Du · United States Jeong-Rae Kim · South Korea

This page summarises published research for orientation; it is not medical or professional advice.