Aims & Scope
Journal of Antioxidant Activity (JAA) publishes peer-reviewed research on the biochemistry, mechanisms, and health implications of antioxidants across nutritional, pharmacological, and clinical contexts. We focus on oxidative stress biology, antioxidant defense systems, and therapeutic applications in human health and disease.
Research Scope: Tiered Structure
Antioxidant Biochemistry & Mechanisms
Fundamental research on antioxidant molecules, enzymatic systems, and cellular defense mechanisms against oxidative damage.
- Enzymatic antioxidants (SOD, catalase, glutathione peroxidase, thioredoxin)
- Non-enzymatic antioxidants (vitamins C/E, carotenoids, polyphenols, flavonoids)
- Redox signaling pathways (Nrf2, NF-κB, MAPK cascades)
- Mechanisms of free radical scavenging and electron transfer
- Structure-activity relationships of antioxidant compounds
- Mitochondrial antioxidant systems and bioenergetics
Oxidative Stress in Disease
Clinical and translational research linking oxidative stress to pathophysiology, disease progression, and therapeutic targets.
- Cardiovascular disease (atherosclerosis, hypertension, ischemia-reperfusion)
- Neurodegenerative disorders (Alzheimer's, Parkinson's, ALS)
- Metabolic diseases (diabetes, obesity, metabolic syndrome)
- Cancer biology (oxidative DNA damage, tumor microenvironment)
- Inflammatory diseases (rheumatoid arthritis, IBD, COPD)
- Aging and age-related pathologies
Antioxidant Interventions & Clinical Trials
Evidence-based research on antioxidant supplementation, dietary interventions, and therapeutic applications in human populations.
- Randomized controlled trials of antioxidant supplements
- Dietary antioxidant intake and health outcomes
- Bioavailability and pharmacokinetics of antioxidants
- Antioxidant therapy in disease management
- Dose-response relationships and safety profiles
- Nutrigenomics and personalized antioxidant strategies
Analytical Methods & Biomarkers
Development and validation of assays for measuring antioxidant capacity, oxidative damage, and redox status in biological systems.
- In vitro antioxidant activity assays (DPPH, ABTS, ORAC, FRAP)
- Oxidative stress biomarkers (MDA, 4-HNE, isoprostanes, protein carbonyls)
- Advanced analytical techniques (LC-MS, GC-MS, EPR spectroscopy)
- Cellular and animal models for oxidative stress assessment
- Method validation and standardization protocols
- High-throughput screening platforms
Natural Products & Phytochemistry
Discovery and characterization of antioxidant compounds from natural sources with demonstrated biological activity.
- Medicinal plant extracts with validated antioxidant properties
- Isolation and structural elucidation of bioactive compounds
- Ethnopharmacological studies with mechanistic validation
- Marine and microbial sources of novel antioxidants
- Synergistic effects of phytochemical mixtures
Food Science & Nutrition
Antioxidant-focused research in food systems, preservation, and nutritional interventions.
- Antioxidant-rich foods and functional ingredients
- Effects of processing on antioxidant content and activity
- Food preservation using natural antioxidants
- Dietary patterns and oxidative stress status
- Encapsulation and delivery systems for antioxidants
Specialized Applications
Antioxidant research in specific physiological contexts and emerging therapeutic areas.
- Exercise physiology and sports nutrition
- Reproductive health and fertility
- Dermatology and skin health
- Ophthalmology and retinal oxidative stress
- Oral health and periodontal disease
- Wound healing and tissue repair
Advanced Technologies & Frontiers
Cutting-edge approaches integrating novel technologies with antioxidant research (subject to additional editorial review).
- Nanotechnology-based antioxidant delivery systems
- AI/machine learning for predicting antioxidant activity
- Gene therapy targeting antioxidant pathways
- Epigenetic regulation of antioxidant gene expression
- Gut microbiome-antioxidant interactions
- Systems biology approaches to redox networks
Out of Scope: Explicit Exclusions
General Nutrition Studies
Dietary interventions or nutritional epidemiology without specific focus on oxidative stress biomarkers or antioxidant mechanisms. Rationale: Insufficient mechanistic connection to antioxidant biology.
Descriptive Phytochemistry
Plant screening studies reporting only total phenolic content or basic DPPH assays without biological validation, mechanistic insight, or structure-activity analysis. Rationale: Lacks translational relevance.
Non-Mechanistic Clinical Reports
Case reports, observational studies, or clinical trials that do not measure oxidative stress biomarkers or antioxidant status. Rationale: Does not advance understanding of antioxidant-disease relationships.
Purely Computational Studies
In silico predictions or molecular docking studies without experimental validation of antioxidant activity or biological effects. Rationale: Requires empirical confirmation.
Cosmetic Formulations
Product development or formulation studies focused solely on cosmetic applications without rigorous biological assessment of antioxidant efficacy. Rationale: Outside biomedical research scope.
General Toxicology
Toxicological studies where oxidative stress is a secondary endpoint rather than the primary research focus. Rationale: Better suited for toxicology-specific journals.
Article Types & Editorial Priorities
Editorial Standards & Requirements
Reporting Guidelines
- CONSORT for randomized controlled trials
- STROBE for observational studies
- PRISMA for systematic reviews
- ARRIVE for animal research
- MIQE for qPCR experiments
- MIAME for microarray studies
Data & Transparency
- Raw data deposition in public repositories
- Statistical analysis code availability
- Detailed methods for reproducibility
- Conflict of interest disclosure
- Funding source transparency
- Clinical trial registration (ClinicalTrials.gov)
Ethics & Compliance
- IRB/Ethics committee approval for human studies
- IACUC approval for animal research
- Informed consent documentation
- Helsinki Declaration adherence
- 3Rs principles for animal welfare
- Biosafety and biosecurity protocols
Preprint & Publication Policy
- Preprints accepted (bioRxiv, medRxiv, arXiv)
- No prior publication in peer-reviewed journals
- Conference abstracts permitted
- Preprint DOI must be disclosed at submission
- Simultaneous submission prohibited
- Post-publication corrections encouraged
Decision Metrics & Author Expectations
Ready to Submit Your Research?
If your work aligns with our scope and meets our editorial standards, we invite you to submit your manuscript. Our editorial team is committed to fair, rigorous, and timely peer review that advances the field of antioxidant research.
Submit Manuscript
