Study basis
- Define the population, cohort, model system, eligibility criteria, sampling, and relevant clinicopathological context.
- Describe biospecimen collection, processing, storage, timing, and quality controls.
Journal of Cancer Genetics and Biomarkers
Instructions for authors
Prepare a clear, reproducible manuscript that makes its cancer-genetics, genomic, molecular, or biomarker contribution easy to evaluate. Use this guide to confirm fit, report the evidence transparently, complete essential declarations, and assemble consistent submission files.
Before you begin
Resolve scope, article category, policies, and charges before formatting the submission.
JCGB is intended for cancer research in which genetics, genomics, related molecular mechanisms, or biomarker science makes a substantive contribution to the research question, methods, and interpretation. The use of a molecular assay alone does not establish fit.
Select the submission category that most closely represents the work in ManuscriptZone. Follow the category names and fields presented during upload, and contact the editorial office for clarification on category-specific preparation.
Manuscript structure
Organize the paper so editors and reviewers can follow the question, methods, evidence, and interpretation without reconstruction.
Title and abstract
State the study focus precisely. Summarize the objective, design or methods, principal findings, and conclusion without overstating what the evidence establishes.
Introduction
Define the scientific or clinical problem, the evidence gap, and the objective or hypothesis.
Methods
Describe participants or models, specimens, procedures, measurements, quality controls, outcomes, software, and statistical analysis in enough detail for evaluation and reproducibility.
Results
Report findings in a logical order, distinguish prespecified from exploratory analyses, and present effect estimates and uncertainty where relevant.
Discussion and conclusion
Interpret the results against the study question and existing evidence. Address limitations, alternative explanations, generalizability, and the boundary between association and demonstrated clinical benefit.
References
Check every citation for completeness and consistency, including persistent identifiers where available.
Cancer genetics and biomarker reporting
Make the biological context, measurement process, validation stage, and limits of inference explicit.
Molecular reporting
- Identify platforms, reagents, software versions, reference genome or transcript set, annotation, filtering, and classification methods.
- Distinguish inherited or germline findings from acquired or somatic alterations.
Biomarker evidence
- State the biomarker role and intended context of use.
- Separate discovery, assay characterisation, analytical validation, clinical validation, and evaluation of clinical utility.
- Identify training, tuning, and independent validation sets where applicable.
Analysis and reproducibility
- Explain endpoints, thresholds, missing data, multiplicity, batch effects, confounding, model calibration, and sensitivity analyses as relevant.
- Provide data, code, and materials access details or clearly justified restrictions.
Use the reporting guideline that fits the study
Consult the EQUATOR Network and apply an appropriate guideline where relevant, such as REMARK, STARD, TRIPOD, CONSORT, STROBE, PRISMA, or ARRIVE. Include the completed checklist when the submission system requests it.
Ethics and transparency
Include the declarations relevant to the work and ensure they agree across the manuscript and submission form.
- Ethics oversight: state approval or exemption details for human or animal research where applicable.
- Consent and privacy: describe informed consent and safeguards for participants or identifiable information.
- Trial registration: provide registration information for applicable clinical studies.
- Authorship: list author contributions and confirm that authorship reflects the work performed.
- Funding: identify funding sources and explain any sponsor role in design, analysis, interpretation, or reporting.
- Competing interests: disclose relevant financial and non-financial interests for all authors.
- Data and materials: include access conditions, repository identifiers, or a clear explanation of justified restrictions.
- Related work: identify overlapping manuscripts, preprints, or reused material for editorial assessment.
Submission package
Complete, internally consistent files allow the editorial team to assess the work as submitted.
- Main manuscript: complete text, references, declarations, and clearly identified sections.
- Title-page information: author names, affiliations, corresponding-author details, and contributions.
- Figures and tables: readable labels, defined units, complete legends, and citations matching the text.
- Supplementary files: clearly labelled methods, protocols, data, analyses, or reporting checklists cited from the manuscript.
- Cover letter: concise explanation of the research question, principal contribution, journal fit, and information the editor should know.
- Final consistency check: align the title, abstract, results, figures, conclusion, declarations, and submission-form metadata.
Follow the current upload fields
File types, category-specific fields, and any additional declarations shown in ManuscriptZone should be completed as presented. Contact the editorial office if a requirement is unclear.
When revising
Make the response traceable so each editorial and reviewer point can be evaluated against the revised manuscript.
Respond to every point in a structured letter. Quote or summarize each comment, explain the action taken, and identify the exact location of the change. Where a requested change is not made, provide a concise scientific rationale.
After revision, recheck the abstract, figures, tables, conclusions, supplementary files, data statements, and declarations so they remain consistent with the updated manuscript.
Author resources
Use the current journal pages for charges, licensing, data guidance, and optional language support.
Ready to prepare your JCGB submission?
Confirm journal fit, complete the submission package, review current charges and policies, then continue to ManuscriptZone.