Aims & Scope
Journal of Transgenics (JTR) publishes fundamental research on gene manipulation technologies, transgenic organism development, and molecular mechanisms underlying genetic engineering across species. We focus on basic science investigations that advance our understanding of gene transfer, expression, and functional genomics.
Core Research Domains
Gene Editing Technologies Tier 1
- CRISPR-Cas systems: mechanism, specificity, off-target analysis
- TALENs, zinc finger nucleases, and base editors
- Prime editing and epigenome editing technologies
- Delivery systems for gene editing components
- Molecular mechanisms of DNA repair pathways in editing
- Comparative analysis of editing efficiency across systems
"Mechanistic analysis of Cas9 conformational changes during target DNA recognition and cleavage using structural biology approaches"
Transgenic Organism Development Tier 1
- Gene transfer methods: microinjection, electroporation, viral vectors
- Transgene integration patterns and chromosomal stability
- Germline transmission and inheritance patterns
- Transgenic plant models: transformation protocols, regeneration
- Transgenic animal models: mice, rats, zebrafish, insects
- Molecular characterization of transgenic lines
"Development of novel Agrobacterium-mediated transformation protocol for recalcitrant plant species with molecular validation of T-DNA integration sites"
Gene Expression & Regulation Tier 1
- Promoter engineering and regulatory element design
- Tissue-specific and inducible expression systems
- Transgene silencing mechanisms and prevention strategies
- RNA interference and post-transcriptional regulation
- Epigenetic modifications affecting transgene expression
- Gene dosage effects and position-independent expression
"Comparative analysis of synthetic promoters for stable, high-level transgene expression in mammalian cells with chromatin accessibility profiling"
Molecular Mechanisms & Genomics Tier 1
- Genome-wide analysis of transgene insertion effects
- Transcriptomic profiling of transgenic organisms
- Proteomic and metabolomic changes in transgenic systems
- Gene targeting and homologous recombination mechanisms
- Transposon-mediated mutagenesis and gene discovery
- Functional genomics using transgenic approaches
"Whole-genome sequencing reveals unintended chromosomal rearrangements in CRISPR-edited cell lines with functional impact assessment"
Secondary Focus Areas
Methodological Innovations
Novel techniques for gene delivery, selection markers, reporter systems, and molecular validation methods. Includes advances in DNA sequencing, PCR-based genotyping, and high-throughput screening of transgenic lines.
Comparative Transgenesis
Cross-species comparisons of gene transfer efficiency, expression patterns, and molecular outcomes. Studies examining evolutionary conservation of regulatory elements and transgene function across organisms.
Synthetic Biology Applications
Design and construction of synthetic genetic circuits, biosensors, and metabolic pathways in transgenic systems. Molecular characterization of engineered biological functions.
Computational Tools
Bioinformatics approaches for transgene design, off-target prediction, integration site analysis, and expression optimization. Machine learning applications in predicting transgenic outcomes.
Molecular Biotechnology
Transgenic production of recombinant proteins, enzymes, and biomolecules. Molecular engineering of biosynthetic pathways and metabolic flux analysis in transgenic organisms.
Gene Function Studies
Use of transgenic models for elucidating gene function, protein-protein interactions, and cellular signaling pathways. Molecular phenotyping and functional validation studies.
Emerging Research Areas
Next-Generation Editing
RNA-guided nucleases beyond CRISPR-Cas9, including Cas12, Cas13, and novel editing platforms. Molecular mechanisms of emerging gene editing technologies and their optimization.
Mitochondrial Genome Engineering
Techniques for mitochondrial DNA manipulation, organellar gene transfer, and molecular analysis of mitochondrial transgene expression and inheritance.
Single-Cell Transgenics
Single-cell analysis of transgene expression heterogeneity, clonal variation, and molecular profiling of individual transgenic cells using omics technologies.
AI-Assisted Design
Machine learning models for predicting optimal transgene design, regulatory element selection, and integration site effects. Computational optimization of gene editing parameters.
Manuscripts in emerging areas undergo additional editorial review to ensure alignment with journal scope and scientific rigor. Authors should clearly articulate the fundamental molecular biology contribution.
Article Types & Priorities
Expedited Review
- Original Research Articles (full-length studies with novel findings)
- Methods & Protocols (validated, reproducible techniques)
- Systematic Reviews & Meta-Analyses (comprehensive literature synthesis)
- Technical Advances (breakthrough technologies with validation)
Regular Review Process
- Short Communications (preliminary but significant findings)
- Data Notes (high-quality datasets with molecular characterization)
- Perspectives & Commentaries (expert analysis of recent advances)
- Review Articles (focused reviews on specific topics)
Limited Acceptance
- Case Reports (only if exceptional molecular insights)
- Opinion Pieces (must include substantial scientific content)
- Letters to Editor (responses to published articles)
- Conference Abstracts (not accepted as standalone submissions)
Editorial Standards & Requirements
Reporting Guidelines
- ARRIVE 2.0 for animal studies
- MIQE for qPCR experiments
- MIAME for microarray data
- STROBE for observational studies
- PRISMA for systematic reviews
- Detailed methods for reproducibility
Data Availability
- Raw data deposition in public repositories
- Sequence data in GenBank/EMBL/DDBJ
- Structural data in PDB/EMDB
- Proteomics data in PRIDE/ProteomeXchange
- Code availability for computational analyses
- Material sharing agreements
Ethics & Compliance
- Institutional biosafety approval required
- Animal ethics committee approval (IACUC)
- Adherence to national GMO regulations
- Conflict of interest disclosure
- Funding source transparency
- Author contribution statements
Preprint & Prior Publication
- Preprints on bioRxiv/arXiv accepted
- Conference presentations allowed
- No duplicate publication
- Preprint DOI must be disclosed
- Significant new data required if preprinted
- Transparent version history
Editorial Performance Metrics
Ready to Submit?
If your research focuses on fundamental molecular mechanisms of transgenesis, gene editing technologies, or transgenic organism development, we invite you to submit your manuscript. Our editorial team is committed to rigorous peer review and rapid publication of high-quality science.
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